Study indicates endocrine disruptors may contribute to liver disease

Greek scientists have concluded that endocrine disrupting chemicals may play a significant role in contributing to the development of nonalcoholic fatty liver disease (NAFDL) by altering insulin resistance in humans.

The researchers reviewed currently available literature on the effects of known endocrine disrupting chemicals including dioxins, bisphenol A (BPA), phthalates and persistent organic pollutants (POPs) to identify pathways that might contribute to the development of NAFDL in humans. They identified that certain chemicals may contribute to the disease via direct toxic effects on the liver as well as increasing insulin resistance which can lead indirectly to the disease. The authors therefore conclude that such chemicals may play a significant role in increasing the prevalence of NAFLD worldwide, but highlight that further studies are needed to confirm this.

The research is published in the journal Current Molecular Medicine.

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