The offspring of pregnant mice exposed to titanium dioxide nanoparticles may have reduced sperm counts and take longer to have their first litter, according to a Danish study. A team led by Karin SØrig Hougaard from the National Research Centre for the Working Environment in Copenhagen exposed mice to the nanoparticles and monitored daily sperm production (DSP) in their offspring.
The researchers also exposed male mice to carbon black nanoparticles. This exposure appeared to affect sperm production two generations down the line. “The mechanism of effect might differ between types of particles, and for carbon black the effect seems confined to the male germline,” say the researchers.
The research will be published in Reproductive Toxicology.