Brazil and China are keen to join the International Cooperation on Alternative Test Methods (ICATM), according to minutes from the last meeting of the European Reference Laboratory for Alternatives to Animal Testing’s (EURL-Ecvam) Scientific Advisory Committee (Esac).
Members of ICATM are working together on test method assessment and prioritisation for validation. They are also trying to develop harmonised test method recommendations, which would be endorsed by all ICATM members. Such endorsement would help recommendations to gain regulatory acceptance, suggested Patric Amcoff, policy advisor on alternative methods at EURL-Ecvam.
The ICATM collaborative platform includes EURL-Ecvam, the US Interagency Coordinating Committee on the Validation of Alternative Methods, Health Canada, the Japanese Center for the Validation of Alternative Methods and the Korean Centre for the Validation of Alternative Methods.
Also discussed at the June meeting were issues relating to alternative tests for genotoxicity, and carcinogenicity testing, including a high false positive rate. EURL-Ecvam is developing a strategy on genotoxicity assessment.
The next Esac meeting will take place in Spring 2014, when the committee aims to endorse its working group report on the human cell line activation test (h-CLAT) assay (GBB 24 May 2013).