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EURL Ecvam recommends in vitro carcinogenicity test

The European Union Reference Laboratory for Alternatives to Animal Testing (EURL Ecvam) has recommended a cell transformation assay (CTA) for carcinogenicity testing.

The in vitro test uses rodent Bhas 42 cells, which change their growing behaviour when exposed to carcinogens. EURL Ecvam considers that the CTA can “provide important information on the carcinogenicity potential of substances when used within integrated approaches for assessment and testing”.

The recommendation is partly based on the results of a Japanese validation study and was developed in consultation with EU regulators, stakeholders and international partners. 

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