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Date -
Title PBPK modelling for quantitative in vitro-in vivo extrapolation
Organiser Altertox Academy
Location KU Leuven - Leuven, Belgium

Physiology-based (pharmaco)kinetic PB(P)K modelling has become a promising tool to predict plasma and/or tissue exposure to xenobiotics based on in vitro disposition data. While physiological parameters that characterize the target population have been largely implemented in several PB(P)K platforms, further consensus building is needed with respect to the quality requirements of in vitro data used for a successful bottom-up modelling approach. Therefore, this workshop will focus on improved integration of in vitro drug disposition assessments with the latest developments in the field of PB(P)K-based prediction. Special attention will also be given to prediction of (tissue) partition coefficients.

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