Scientists have published a review article examining the potential for bisphenol A (BPA) to act as a potent endocrine disrupting chemical through non-classical mechanisms.
The researchers outline the traditional scientific view, which considers BPA to act as a weak endocrine disruptor, based on evidence indicating the chemical has a low level of interaction with oestrogen receptors in the cell. However, they highlight evidence from in vivo animal studies which have shown that BPA can have significant endocrine disrupting effects even when the level of exposure is low.
The authors therefore discuss the possibility that BPA has strong oestrogenic activity, which occurs by alternative mechanisms of action and not via oestrogen receptors. They highlight mounting evidence suggesting that the chemical can elicit cellular responses at low concentrations through a variety of pathways, with the same or even greater effects than those mediated through oestrogen receptors.
The paper is published in the journal Molecular and Cellular Endocrinology.