The Beginner's Guide to Toxicology

Welcome to Toxicology for Beginners, an exciting elearning course brought to you by Chemical Watch. In this structured course, spanning eighteen distinct modules, you’ll be given a solid introduction to Toxicology with specific reference to REACH and other regulatory frameworks.

The course is designed to be as engaging as it is informative, utilising a rich mix of content types and a class-leading elearning delivery platform. The course represents exceptional value for money, and offers all the convenience of an online course.

What's included?

18 modules

The course delivers a complete introduction to the topic - a full breakdown of learning outcomes can be viewed below.

600 items

The full picture - in all, five hours of professionally-designed training materials.

400 audios

Engaging commentary throughout - clearly explaining key points and concepts to trainees.

120 questions

Instant feedback of your progress, with 120 pop-quiz questions throughout.

18 handouts

18 printable course notes PDFs compliment each of the module, with additional information.

And more...

The course includes over 100 videos and a useful glossary of terms. Trainees have access to materials for a full 12 months following enrolment (or longer by arrangement).

Who is this course for?

  • HSE professionals
  • Occupational hygienists
  • Authors of SDS
  • Regulatory staff and business managers involved in Substance Information Exchange Forum (SIEF) or consortium meetings
  • R&D chemists
  • Anyone involved in classification and labelling
  • Anyone involved in REACH regulations, but also other chemical control regulations
  • New recruits to companies needing a quick start
    to understanding toxicological terms

Module by module: Learning Outcomes


Introduction to toxicology
  • Define the term toxicology
  • Describe the different ways in which chemicals can cause harm
  • Explain the impact that physical forms can have on toxicity and exposure

Genetic toxicology
  • Explain the differences between DNA, genes and chromosomes
  • Define the terms mutagenicity and genotoxicity
  • Describe the types of effects that can occur (on genes, chromosomes and DNA itself ) as a result of chemical exposure
  • Explain the significance of genetic toxicology and its relationship with carcinogenesis
  • Describe the common testing approach and methods that are used for genetic toxicology
  • Outline the REACH requirements in relation to this endpoint

How to assess for toxicity
  • Define the terms In vitro, ex vivo, in vivo
  • Explain what is meant by the term “alternative methods” and how the 3R’s form part of these
  • Outline the sections of the REACH Regulation which encourage the use of alternatives
  • Describe what other non-animal alternatives are available for finding test data
  • Explain what is meant by in vivo studies and two of the main issues regarding their use

Reproductive and Developmental effects
  • Define the terms reproductive toxicology and developmental effects
  • Give examples of common adverse effects that are typical of reproductive or developmental toxins
  • Outline the common testing strategies that are used to investigate such effects
  • Outline the REACH requirements in relation to this endpoint

Risk, hazard and exposure
  • Define the terms risk, hazard and exposure
  • Describe the three main routes of exposure and the significance to toxicity

Chemical allergies
  • Describe how an allergy develops
  • Define the term allergic contact dermatitis
  • Explain the difference between allergic contact dermatitis and irritant contact dermatitis
  • Define the terms respiratory hypersensitivity, occupational asthma and work related asthma
  • Explain the significance of developing an allergy to a chemical in the work place
  • Outline the common testing methods used to detect respiratory and skin sensitisers
  • Outline the REACH requirements in relation to this endpoint

Dose response effects
  • Define the term dose and response
  • Draw a “typical” dose response curve and describe the key parts
  • Explain what is meant by the term “threshold”
  • Explain the difference between thresholded and non thresholded effects with examples
  • Define the terms Noael and Loael

EMERGING CONCEPTS: AOP
  • Define the term adverse outcome pathways (AOP)
  • Identify the three main pieces of information which is required to develop an AOP
  • Explain the usefulness of AOP in toxicology
  • Identify two current issues related to the use of AOP

Irritation and corrosion
  • Define the terms Local effect, irritant and corrosive
  • Explain what is meant by irritant contact dermatitis and how it typically occurs
  • Explain the common testing methods that are used to detect chemical corrosives and irritants
  • Outline the REACH requirements in relation to this endpoint

EMERGING CONCEPTS: Combined effects

  • Explain the current issues related to toxicity testing for mixtures
  • Describe what is meant by the terms additive, synergistic, antagonistic and potentiation
  • Outline the approaches currently taken in Europe when considering combined effects

Toxicokinetics
  • Define the term toxicokinetics
  • Explain what happens at each of the respective stages;
  • absorption, distribution, metabolism and excretion
  • Outline the REACH requirements in relation to toxicokinetics

EMERGING CONCEPTS: Endocrine disruptors
  • Describe what is meant by the endocrine system and its function within living organisms
  • Explain the term “endocrine disruptor” and “endocrine active” substances
  • Describe what is meant by “low dose effects” and “non monotonic dose response”
  • Explain how endocrine disruptors are dealt with under the REACH Regulation
  • Outline the key issues related to the assessment of endocrine disruptors

Acute Toxicity
  • Define the term acute toxicity and explain how it differs to repeated dose toxicity
  • Explain why it is not possible to use acute toxicity data to predict repeated dose effects
  • Describe the common testing strategies that can be used to assess acute toxicity
  • Outline the REACH requirements in relation to this endpoint

EMERGING CONCEPTS: Nanoparticles
  • Explain what is meant by the term “nanoparticle”
  • Give two examples of nanomaterials
  • Outline the current key issues related to nanoparticles
  • Explain how nanoparticles are dealt with under REACH

Repeated dose toxicity
  • Define the term “systemic effect “and target organ effect with examples
  • Explain the different types of repeated dose studies and the basic differences between these
  • Describe the common testing strategies that are used for repeated dose toxicity
  • Outline the REACH requirements in relation to this endpoint

Toxicology and REACH
  • Define the term DNEL and explain the different types which may be derived
  • Outline the process for deriving a DNEL
  • Explain what is meant by risk characterisation and the difference between quantitative and qualitative risk characterisation
  • Explain the different approaches that can be taken with regards to exposure modelling and the difference between a Tier 1 and Tier 2 model
  • Define the term risk characterisation ratio and its significance
  • Describe the difference between the extended safety data sheet and a safety data sheet and when these documents need to be made available
  • Describe the changes which the introduction of the CLP Regulation has had on the duties of suppliers within Europe
  • Define the term “CMR” and “PBT” and the implications under REACH

Carcinogens
  • Define the terms Carcinogenicity, Benign
  • and malignant tumours, Genotoxic and non
  • genotoxic carcinogens
  • Outline the steps in carcinogenesis
  • Describe the common causes of cancer
  • Describe the common testing strategies for detecting chemical carcinogens
  • Outline the REACH requirements in relation to this endpoint

Toxicological testing requirements and REACH
  • Describe the underlying principle behind REACH
  • in the context of human health
  • Describe where the human health endpoints are
  • listed in the REACH Regulation and explain why as the
  • tonnage being placed on the market increases so does
  • the testing requirements
  • Explain what is meant by standard information requirements and where these can be located within the REACH Regulation
  • Explain the kind of information that can
  • be derived from Column 2 to the standard
  • information requirements
  • Explain what kind of information can be obtained from Annex XI
  • Define the terms “Adaptation”, “Data Waiver”, “weight of evidence”, “exposure based waiving” AND “read across”

About the expert

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Laura Robinson is a qualified toxicologist & chemist with over ten years' experience in health, safety and environmental issues, as well as chemical compliance.

Laura is an accomplished toxicology trainer, consultant and author of two published books on toxicology.

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Pricing

No of Users

Enrolment fee

EUR (GBP | USD)

Per - user rate

EUR (GBP | USD)

Per - user discount (%)

1 €597 (£437 | $679) €597 (£437 | $679) 0%
2 €814 (£597| $925) €407 (£299 | $462.50) 32%
3 €1,019 (£747 | $1,155) €339.67 (£249 | $385) 43%
4 €1,207 (£887 | $1,369) €301.75 (£222| $342.25) 49%
5 €1,337 (£987 | $1,525) €267.40 (£197 | $305) 55%
10 €1,847 (£1,357 | $2,097) €184.70 (£136 | $209.70) 69%
20 €2,677 (£1,967 | $3,039) €133.85 (£98 | $151.95) 77%
30 €3,357 (£2,467 | $3,815) €111.90 (£82| $127.17) 81%
40 €3,987 (£2,927 | $4,525) €99.68 (£73 | $113.13) 83%
50 €4,447 (£3,267 | $5,049) €88.94 (£65 | $100.98) 85%

Chemical Watch subscribers qualify for €50 off the single trainee rate (only). Group rates are already discounted.
For rates for groups of more than fifty trainees, please contact us today by clicking here.

Trainees have access to course materials for 12 months from enollment, or longer by arrangement.


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